Name: Anti-Lamin A/C antibody
Price: 224.00 USD

Overview
- Lamin A/C is a protein encoded by the LMNA gene which is approximately 74, 1 kDa. Lamin A/C is localised to the nucleus and nuclear envelope. It is involved in the apoptosis and survival caspase cascade, mitotic cell cycle, unfolded protein response and arrhythmogenic right ventricular cardiomyopathy. It plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics and is required for normal development of the peripheral nervous system and skeletal muscle. It is also required for osteoblasto genesis and bone formation. Lamin A/C is expressed in the arteries. Mutations in the LMNA gene can result in Emery-Dreifuss muscular dystrophy 2. The antibody STJ93885 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at S392.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of S392.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Prelamin-A/C [Cleaved Into-Lamin-A/C; 70 Kda Lamin; Renal Carcinoma Antigen Ny-Ren-32] (Gene ID:4000; UniProt:P02545)
  
  * For research use only

Applications

Application

WB; IHC (paraffin); IF; ELISA

Application	Dilutions
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:20000

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from HeLa cells, using Lamin A/C Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-Lamin A/C antibody

Anti-Lamin A/C antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.

Immunofluorescence analysis of HeLa cells, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from HeLa cells, using Lamin A/C Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-Lamin A/C antibody

Anti-Lamin A/C antibody

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