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Overview
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Laminin alpha-1 is a protein encoded by the LAMA1 gene which is approximately 337 kDa. Laminin alpha-1 is secreted into the extracellular space. It is involved in the integrin pathway, ERK signalling and MET promotes cell motility. It is thought to mediate binding to cells via a high affinity receptor resulting in migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin alpha-1 is expressed in the gall bladder, intestine, lung, liver and pancreas. Mutations in the LAMA1 gene may result in Poretti-Boltshauser syndrome. STJ93888 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Laminin alpha-1 protein.
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