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Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)

Anti-Interleukin-4 Receptor Alpha chain (Il-4R) extracellular domain (CD124). IgG fraction (monoclonal)

Catalog Number:

A001277484AUS

Mfr. No.:

AUST_MR-441-4; AUST_MR-441-7

Price:

$520

Size:

Quantity:

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- Overview
  - IgG fraction from mouse monoclonal antibody (clone 6B1/E7) obtained by immunization of mice with the extra-cellular domain of interleukin 4 receptor alpha chain (38 kDa). The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Formulation
    
    Solution at 0.95 mg/mL in PBS
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This antibody can be used for ELISA assay (1:2,000 dilution). The IL-4R alpha chain binds both IL-4 and IL-13 and activates many common signal transduction pathways. The extra-cellular domain, also called CD124, inhibits IL-4-mediated cell proliferation and IL-5 up-regulation by T-cells. The IL-4/IL-13 responses are involved in the regulation of the differentiation of CD4+ T cells and class switching to IgG1 and IgE.
- Reference
  - Nelms, K. et. al. (1999) Annu. Rev. Immunol. 17, 701 - 738

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