Anti-ILF3 antibody

Catalog Number:

A001034239STJ

Mfr. No.:

STJ24197

Price:

$297

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Overview
- This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ILF3 (NP_036350. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Interleukin Enhancer-Binding Factor 3; Double-Stranded Rna-Binding Protein 76; Drbp76; M-Phase Phosphoprotein 4; Mpp4; Nuclear Factor Associated With Dsrna; Nfar; Nuclear Factor Of Activated T-Cells 90 Kda; Nf-At-90; Translational Control Protein 80; Tcp80 (Gene ID:3609; UniProt:Q12906)
  
  * For research use only