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Overview
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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Overview
Immunohistochemistry of paraffin-embedded human liver damage using IL4 antibody (STJ27616) at dilution of 1:100 (40x lens).
Anti-IL4 antibody
Anti-IL4 antibody
Catalog Number:
A001036016STJ
Mfr. No.:
STJ27616
Price:
$297
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