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Overview
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The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded mouse heart using IL18BP antibody (STJ28528) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of A549 cells using IL18BP antibody (STJ28528). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using IL18BP antibody (STJ28528) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-IL18BP antibody
Anti-IL18BP antibody
Catalog Number:
A001036622STJ
Mfr. No.:
STJ28528
Price:
$297
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