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Overview
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This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
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- Properties
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Overview
Immunofluorescence analysis of MCF-7 cells using IKZF3 antibody (STJ29426). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using IKZF3 Antibody (STJ29426) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-IKZF3 antibody
Anti-IKZF3 antibody
Catalog Number:
A001037410STJ
Mfr. No.:
STJ29426
Price:
$297
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