Name: Anti-IFIH1 antibody
Price: 297.00 USD

Overview
- DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human IFIH1 (NP_071451. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Interferon-Induced Helicase C Domain-Containing Protein 1; Clinically Amyopathic Dermatomyositis Autoantigen 140 Kda; Cadm-140 Autoantigen; Helicase With 2 Card Domains; Helicard; Interferon-Induced With Helicase C Domain Protein 1; Melanoma Differentiation-Associated Protein 5; Mda-5; Murabutide Down-Regulated Protein; Rig-I-Like Receptor 2; Rlr-2; Rna Helicase-Dead Box Protein 116 (Gene ID:64135; UniProt:Q9BYX4)
  
  * For research use only