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Overview
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Villin is an actin-binding glycoprotein that serves an important role in the maintenance of the microvillibrush border in gastrointestinal (GI) mucosal epithelium and its associated tumors. Recentimmunohistochemical studies with villin have shown that villin is not only expressed in carcinomas ofthe gastrointestinal tract, but also in renal cell carcinomas, pancreatic carcinomas, endometrialcarcinomas, as well as carcinomas of the ovary and lungs. In addition, positive villin expression may beseen in neuroendocrine/carcinoid tumors of the GI tract and lungs.
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