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Overview
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CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilicbinding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, andintegrins. CD56 is involved in cellìcell adhesion of neural cells during embryogenesis and is expressedon most neuroectodermally derived tissues.1-3 In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in mostNK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms.
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