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Overview
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Programmed death-1 (PD1) is a member of the CD28 family of receptors that includes CD28, cytotoxicT-lymphocyte-associated antigen 4 (CTLA-4), inducible costimulator (ICOS), and B-and T-lymphocyteattenuator. These receptors play a role in the cellular immune response. For example, CD28 serves asa costimulatory receptor that enhances T-cell activation, whereas CTLA-4 serves as an inhibitor of T-cellactivation. PD1 also has an inhibitory function on T cells and B cells, and is important in peripheraltolerance. There are at least 2 ligands for PD1, PD-L1, and PD-L2, which are expressed on a range ofcells.
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- Properties
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Overview