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Overview
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CD71, also known as transferrin receptor, is a membrane glycoprotein that mediates the uptake of ironfrom transferrin for hemoglobin synthesis in erythroid cells. Early erythroid precursors anderythroblasts contain the highest mass of transferrin receptors, and expression is lost as these cellscease hemoglobin synthesis and mature into erythrocytes. Therefore, anti-CD71 is a useful marker forhighlighting erythroid precursors in bone marrow specimens.Increased CD71 expression is also associated with active cell growth including neoplastic tumor growthand may be seen in various carcinomas such as thyroid carcinomas, lung carcinomas, breastcarcinomas, hepatocellular carcinomas and colorectal carcinomas.
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Overview