Anti-HSD11B2 antibody

Catalog Number:

A001017215STJ

Mfr. No.:

STJ110380

Price:

$297

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Overview
- There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Corticosteroid 11-Beta-Dehydrogenase Isozyme 2; 11-Beta-Hydroxysteroid Dehydrogenase Type 2; 11-Dh2; 11-Beta-Hsd2; 11-Beta-Hydroxysteroid Dehydrogenase Type II; 11-Hsd Type II; 11-Beta-Hsd Type II; Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase; 11-Beta-Hsd; Short Chain Dehydrogenase/Reductase Family 9c Member 3 (Gene ID:3291; UniProt:P80365)
  
  * For research use only