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Overview
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Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
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- Properties
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Overview
Immunofluorescence analysis of 293T cells using HNRNPL antibody (STJ114321) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded mouse brain using HNRNPL antibody (STJ114321) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using HNRNPL antibody (STJ114321) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human placenta using HNRNPL antibody (STJ114321) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using HNRNPL antibody (STJ114321) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-HNRNPL antibody
Anti-HNRNPL antibody
Catalog Number:
A001021290STJ
Mfr. No.:
STJ114321
Price:
$297
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