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Overview
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HIF-1 alpha is a protein encoded by the HIF1A gene which is approximately 92, 6 kDa. HIF-1 alpha is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation, removal of Cdc6, HIF repressor pathways, signalling by PTK6 and the notch signalling pathway. It functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 alpha is expressed in most tissues with highest levels in kidney and heart. Mutations in the HIF1A gene may result in hypoxia and retinal ischemia. STJ93498 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HIF-1 alpha protein.
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