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Overview
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
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Overview
Immunohistochemistry of paraffin-embedded human stomach using HDAC3 antibody (STJ114416) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of HeLa cells using HDAC3 Polyclonal Antibody (STJ114416) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human colon carcinoma using HDAC3 antibody (STJ114416) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using HDAC3 antibody (STJ114416) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse liver using HDAC3 antibody (STJ114416) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of mouse brain, using HDAC3 antibody (STJ114416) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.
Western blot analysis of extracts of various cell lines, using HDAC3 antibody (STJ114416) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.
Anti-HDAC3 antibody
Anti-HDAC3 antibody
Catalog Number:
A001021379STJ
Mfr. No.:
STJ114416
Price:
$297
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