Name: Anti-GRP78/Bip antibody
Price: 224.00 USD

Overview
- GRP78/Bip is a protein encoded by the HSPA5 gene which is approximately 72, 3 kDa. GRP78/Bip is localised to the endoplasmic reticulum lumen, melanosome and cytoplasm. It is involved in pathways such as the unfolded protein response, response to elevated platelet cytosolic Ca2+, cellular response to heat stress and mechanisms of CFTR activation. This protein falls under the heat shock protein 70 family. Its function is in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. It is involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10. GRP78/Bip is expressed in the nervous system, liver, muscle, intestine and pancreas. Mutations in the HSPA5 gene may result in rheumatoid arthritis. STJ97526 was developed from clone 8G3. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This mouse monoclonal antibody binds endogenous levels of GRP78/Bip.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat
  
  Clone
  
  8G3
  
  Immunogen
  
  Synthetic Peptide
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Endoplasmic Reticulum Chaperone Bip; 78 Kda Glucose-Regulated Protein; Grp-78; Binding-Immunoglobulin Protein; Bip; Heat Shock Protein 70 Family Protein 5; Hsp70 Family Protein 5; Heat Shock Protein Family A Member 5; Immunoglobulin Heavy Chain-Binding Protein (Gene ID:3309; UniProt:P11021)
  
  * For research use only