Name: Anti-Glycoprotein 1 of Sin Nombre Virus (SNV). IgG fraction monoclonal antibody. Clone 6C4/H12
Price: 878.00 USD

- Overview
  - Mouse monoclonal antibody IgG fraction (clone 6C4/H12) obtained by immunizing mice with purified recombinant SNV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Formulation
    
    Solution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This antibody can be used in ELISA (1:30,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of SNV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. SNV is the major causative agent of hantavirus pulmonary syndrome in North America and is carried by the deer mouse, Peromyscus maniculatus.
- Reference
  - Boudko, S.P. et al. (2007) J. Mol. Biol. 366, 1538-1544.
    Mir, M.A. & Panganiban, A.T. (2004) J. Virol. 78, 8281-8288.
    Spiropoulou, C.F. et al. (2003) Virology 308, 48-63.
    Chizhikov, V.E. et al. (1995) J. Virol. 69, 8132-8136.

Anti-Glycoprotein 1 of Sin Nombre Virus (SNV). IgG fraction monoclonal antibody. Clone 6C4/H12

Anti-Glycoprotein 1 of Sin Nombre Virus (SNV). IgG fraction monoclonal antibody. Clone 6C4/H12

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