Name: Anti-Glycoprotein 1 of Dobrava Virus (DOBV). IgG fraction monoclonal antibody. Clone 6D4/F12
Price: 878.00 USD

- Overview
  - Mouse monoclonal antibody IgG fraction (clone 6D4/F12) obtained by immunizing mice with purified recombinant DOBV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG3
    
    Formulation
    
    Solution at 0.5 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This antibody can be used in ELISA (1:8,000 dilution) and Western blot (1:8,000 dilution) analysis. It recognizes G1 glycoprotein of DOBV and it has cross reactivity with G1 glycoprotein of Seoul virus (SEOV). Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. DOBV causes hemorrhagic fever with renal syndrome in eastern and central Europe and is carried by two different rodent species, Apodemus flavicollis and Apodemus agrarius.
- Reference
  - Klempa, B. et al. (2004) J. Clin. Microbiol. 42, 1322-1325.
    Vapalahti, O. et al (2003) Lancet Infect. Dis. 3, 653-661.
    Sibold, C. et al (2001) J. Med. Virol. 63, 158-167.
    Avsic-Zupanc, T. et al. (1995) J. Gen. Virol. 76, 2801-2808.

Anti-Glycoprotein 1 of Dobrava Virus (DOBV). IgG fraction monoclonal antibody. Clone 6D4/F12

Anti-Glycoprotein 1 of Dobrava Virus (DOBV). IgG fraction monoclonal antibody. Clone 6D4/F12

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