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Overview
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The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
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Overview
Immunofluorescence analysis of HeLa cells using FLNA antibody (STJ114910) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunoprecipitation analysis of 200ug extracts of Jurkat cells, using 3 ug FLNA antibody (STJ114910). Western blot was performed from the immunoprecipitate using FLNA antibody (STJ114910) at a dilition of 1:1000.
Western blot analysis of extracts of various cell lines, using FLNA antibody (STJ114910) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-FLNA antibody
Anti-FLNA antibody
Catalog Number:
A001021839STJ
Mfr. No.:
STJ114910
Price:
$297
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