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Overview
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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded rat kidney using FADD antibody (STJ28382) at dilution of 1:200 (40x lens).
Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug FADD antibody (STJ28382). Western blot was performed from the immunoprecipitate using FADD antibody (STJ28382) at a dilition of 1:1000.
Western blot analysis of extracts of various cell lines, using FADD antibody (STJ28382) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.
Anti-FADD antibody
Anti-FADD antibody
Catalog Number:
A001036483STJ
Mfr. No.:
STJ28382
Price:
$297
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