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Overview
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Oct‐2 is a transcription factor of the POU homeo‐domain family that binds to the Ig gene octamer sites, regulating B‐ cell‐specific genes. Oct‐2 expression can be used as a marker of B‐cell lineage and differentiation. Germinal center B‐cells, mantle B‐cells, monocytoid B‐cells, and plasma cells show high level expression of Oct‐2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B‐cell lymphoma, Hodgkin lymphoma display increased expression of Oct‐2. Several studies of Oct‐2 expression have shown a low level expression in pre‐B, T‐cell, myelomonocytic, and epithelial cell lines, whereas all mature B‐cell lines have high levels of expression. In spite of scanty evidence for Oct‐2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T‐cell activation.
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