Name: Anti-AMP Alpha antibody
Price: 224.00 USD

Overview
- AMPK alpha1 is a protein encoded by the PRKAA1 gene which is approximately 64 kDa. AMPK alpha1 is localised to the cytoplasm and nucleus. It is involved in RET signalling, mTOR signalling, AMP-activated protein kinase signalling, the regulation of TP53 activity and longevity regulating pathway. It is a catalytic subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, it activates energy-producing pathways and inhibits energy-consuming processes such as protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK alpha1 is expressed in the nervous system, liver, blood, intestine and kidney. Mutations in the PRKAA1 gene may result in obesity. STJ91580 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AMPK alpha1 protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human AMPKalpha1 around the non-phosphorylation site of S496.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  5'-Amp-Activated Protein Kinase Catalytic Subunit Alpha-1; Ampk Subunit Alpha-1; Acetyl-Coa Carboxylase Kinase; Acaca Kinase; Hydroxymethylglutaryl-Coa Reductase Kinase; Hmgcr Kinase; Tau-Protein Kinase Prkaa1 (Gene ID:5562; UniProt:Q13131)
  
  * For research use only