Anti-ERBB2 antibody

Overview
- Goat polyclonal antibody to ERBB2. This protein ia a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases containing a single transmembrane domain and has an approximate molecular weight of 185 kD. ERBB2 contains no ligand binding domain and interacts with other EGF receptor family members to form a heterodimer, stabilize ligand binding, and enhance kinase-mediated downstream signaling. It has been shown to be involved in embryonic development and cancer progression.
  
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Properties
- Host
  
  goat
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat; bovine; canine; avian; donkey; feline; goat; guinea pig; hamster; horse; porcine; rabbit; sheep; simian
  
  Immunogen
  
  Recombinant peptide derived from within residues 1,177 aa to the C-terminus of human ERBB2 produced in E. coli.
  
  Purification
  
  This antibody is epitope-affinity purified from goat antiserum.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS, 20% glycerol and 0.05% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeated freeze-thaw cycles.
  
  Concentration
  
  2 mg/mL
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) (Gene ID:2064)
  
  * For research use only