Anti-EGLN1 antibody

Catalog Number:

A001023621STJ

Mfr. No.:

STJ116768

Price:

$295

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Overview
- The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human EGLN1 (NP_071334. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Egl Nine Homolog 1; Hypoxia-Inducible Factor Prolyl Hydroxylase 2; Hif-Ph2; Hif-Prolyl Hydroxylase 2; Hph-2; Prolyl Hydroxylase Domain-Containing Protein 2; Phd2; Sm-20 (Gene ID:54583; UniProt:Q9GZT9)
  
  * For research use only