Anti-DUSP6 antibody

Anti-DUSP6 antibody

Catalog Number:
A001033797STJ
Mfr. No.:
STJ23447
Price:
$297
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      • Overview
        • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          mouse; rat
          Immunogen
          Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human DUSP6 (NP_001937. 2).
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
          Storage
          Store at -20°C and avoid freeze-thaw cycles.
          Regulatory Status
          RUO
          Antigen
          Dual Specificity Protein Phosphatase 6; Dual Specificity Protein Phosphatase Pyst1; Mitogen-Activated Protein Kinase Phosphatase 3; Map Kinase Phosphatase 3; Mkp-3 (Gene ID:1848; UniProt:Q16828)

          * For research use only

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1:500-1:2000

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