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Overview
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This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded human trachea using DSG1 antibody (STJ111854) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of rat skin using DSG1 antibody (STJ111854) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using DSG1 antibody (STJ111854) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.
Anti-DSG1 antibody
Anti-DSG1 antibody
Catalog Number:
A001019628STJ
Mfr. No.:
STJ111854
Price:
$297
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