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Overview
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Dihydropyrimidinase catalyzes the conversion of 5, 6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2. 5-kb transcript and a minor 3. 8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
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