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Overview
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This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
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Overview
Immunofluorescence analysis of U-2 OS cells using DNMT1 antibody (STJ119581) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human tonsil using DNMT1 antibody (STJ119581) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse spleen using DNMT1 antibody (STJ119581) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using DNMT1 antibody (STJ119581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-DNMT1 antibody
Anti-DNMT1 antibody
Catalog Number:
A001026308STJ
Mfr. No.:
STJ119581
Price:
$297
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