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Overview
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This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
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Overview
Immunofluorescence analysis of U-2 OS cells using DKC1 antibody (STJ114780) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human lung cancer using DKC1 antibody (STJ114780) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of NIH-3T3 cells using DKC1 antibody (STJ114780) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using DKC1 antibody (STJ114780) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
Anti-DKC1 antibody
Anti-DKC1 antibody
Catalog Number:
A001021723STJ
Mfr. No.:
STJ114780
Price:
$297
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