Anti-DHCR24 antibody

Catalog Number:

A001035823STJ

Mfr. No.:

STJ27355

Price:

$297

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Overview
- This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Delta(24-Sterol Reductase; 24-Dehydrocholesterol Reductase; 3-Beta-Hydroxysterol Delta-24-Reductase; Diminuto/Dwarf1 Homolog; Seladin-1 (Gene ID:1718; UniProt:Q15392)
  
  * For research use only