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Overview
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Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins anddesmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link theintermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domainof desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas theintracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin.Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments. reacts with the 140 kDa desmoglein 3 protein. Furthermore it is not cross reactive with desmoglein 1or desmoglein 2.
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