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Overview
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Desmin is a protein encoded by the DES gene which is approximately 53, 5 kDa. Desmin is localised to the cytoplasm and cell membrane. It is involved in striated muscle contraction, cytoskeletal signalling and mesenchymal stem cell differentiation pathways. It is a muscle-specific class III intermediate filament. They form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures in adult striated muscle. Desmin is expressed in the muscle, heart, intestine, liver and stomach. Mutations in the DES gene may result in muscular dystrophy. STJ97531 was developed from clone 1B12 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of Desmin.
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Overview
Immunohistochemical analysis of paraffin-embedded Mouse Heart Tissue using DesminMouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Mouse Skeletal Muscle Tissue using Desmin (mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Mouse-lung tissue. 1, Desmin monoclonal antibody (1B12) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Immunohistochemical analysis of paraffin-embedded Rat-heart tissue. 1, Desmin monoclonal antibody (1B12) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Immunohistochemical analysis of paraffin-embedded Human-lung tissue. 1, Desmin monoclonal antibody (1B12) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Immunofluorescence analysis of human-uterus tissue. 1, Desmin monoclonal antibody (1B12) (red) was diluted at 1:200 (4°C, overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300 (room temperature, 50min).3, Picture B: DAPI (blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B
Anti-Desmin antibody
Anti-Desmin antibody
Catalog Number:
A001052899STJ
Mfr. No.:
STJ97531
Price:
$224
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