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Overview
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Desmin is a protein encoded by the DES gene which is approximately 53, 5 kDa. Desmin is localised to the cytoplasm and cell membrane. It is involved in striated muscle contraction, cytoskeletal signalling and mesenchymal stem cell differentiation pathways. It is a muscle-specific class III intermediate filament. They form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures in adult striated muscle. Desmin is expressed in the muscle, heart, intestine, liver and stomach. Mutations in the DES gene may result in muscular dystrophy. STJ97531 was developed from clone 1B12 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of Desmin.
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