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Overview
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Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
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Overview
Immunohistochemistry of paraffin-embedded rat heart using DEFA1 antibody (STJ28977) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of HeLa cells using DEFA1 antibody (STJ28977). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using DEFA1 antibody (STJ28977) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
Anti-DEFA1 antibody
Anti-DEFA1 antibody
Catalog Number:
A001037010STJ
Mfr. No.:
STJ28977
Price:
$297
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