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Overview
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Is the broad-spectrum keratin antibody cocktail. It is composed of mouse monoclonalantibody AE1 that recognizes the acidic type I keratins 10, 14, 15, 16, 19, and AE3 that reacts with thebasic type II keratins 1, 2, 3, 4, 5, 6, 7, and 8. Both clones were generated using epidermal keratin asimmunogen. This antibody detects carcinomas of different organ origin, but is most frequently negativein hepatocellular carcinoma, chromophobe RCC, adrenol cortical carcinoma, some clear cell renal cellcarcinomas, and renal oncocytoma. This antibody cocktail can cross-react with other intermediatefilaments, such as glial fibrillary acidic protein, giving a false-positive staining in glial tumors.
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