Anti-CYP27B1 antibody

Catalog Number:

A001018987STJ

Mfr. No.:

STJ111108

Price:

$297

Size:

Quantity:

Add to Cart:

Add to Cart

Overview
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1 alpha position. This reaction synthesizes 1 alpha, 25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 25-195 of human CYP27B1 (NP_000776. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  25-Hydroxyvitamin D-1 Alpha Hydroxylase-Mitochondrial; 25-Ohd-1 Alpha-Hydroxylase; 25-Hydroxyvitamin D(3 1-Alpha-Hydroxylase; Vd3 1a Hydroxylase; Calcidiol 1-Monooxygenase; Cytochrome P450 Subfamily XxvIIb Polypeptide 1; Cytochrome P450c1 Alpha; Cytochrome P450vd1-Alpha; Cytochrome P450 27b1 (Gene ID:1594; UniProt:O15528)
  
  * For research use only