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Overview
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Fibronectin is a protein encoded by the FN1 gene which is approximately 262, 6 kDa. Fibronectin is secreted into the extracellular matrix. It is involved in RET signalling, ERK signalling and the integrin pathway. It is a glycoprotein present in a soluble dimeric form in plasma, and in either a dimeric or multimeric form at the cell surface and in extracellular matrix. It is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defence, and metastasis. Fibronectin is expressed in the nervous system, bone, liver and muscle. Mutations in the FN1 gene may result in calciphylaxis. STJ97039 was developed from clone M9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous Fibronectin protein.
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