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Overview
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This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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- Properties
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Overview
Immunofluorescence analysis of HeLa cells using CUL3 antibody (STJ23291). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human prostate using CUL3 antibody (STJ23291) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human gastric cancer using CUL3 antibody (STJ23291) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CUL3 antibody (STJ23291) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s.
Anti-CUL3 antibody
Anti-CUL3 antibody
Catalog Number:
A001033702STJ
Mfr. No.:
STJ23291
Price:
$297
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