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Overview
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Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
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Overview
Immunofluorescence analysis of U2OS cells using COMT antibody (STJ27956). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat kidney using COMT antibody (STJ27956) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse kidney using COMT antibody (STJ27956) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using COMT antibody (STJ27956) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
Anti-COMT antibody
Anti-COMT antibody
Catalog Number:
A001036209STJ
Mfr. No.:
STJ27956
Price:
$297
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