Name: Anti-Collagen III antibody
Price: 224.00 USD

Overview
- Collagen III is a protein encoded by the COL3A1 gene which is approximately 138, 5 kDa. Collagen III is secreted into the extracellular matrix. It is involved in collagen chain trimerization, the integrin pathway, ERK signalling and the phospholipase-C pathway. It occurs in most soft connective tissues along with type I collagen. It is involved in regulation of cortical development and is the major ligand of ADGRG1 in the developing brain, binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13. Collagen III is expressed in the skin, pancreas, bone, liver and lung. Mutations in the COL3A1 gene may result in Ehlers-Danlos syndrome. STJ97025 was developed from clone Q76 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous Collagen III protein.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; mouse; rat
  
  Clone
  
  Q76
  
  Immunogen
  
  Synthetic Peptide
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Collagen Alpha-1(III Chain (Gene ID:1281; UniProt:P02461)
  
  * For research use only