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Overview
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CK8 is a protein encoded by the KRT8 gene which is approximately 53, 7 kDa. CK8 is localised to the cytoplasm and nucleus. It is involved in cytoskeletal signalling, developmental biology, keratinization and primary focal segmental glomerulosclerosis. It dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells and plays a role in maintaining cellular structural integrity, signal transduction and cellular differentiation. CK8 is expressed in the intestine, liver, lung, pancreas and kidney. Mutations in the KRT8 gene may result in cirrhosis. STJ96957 was developed from clone 8G8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CK8 proteins.
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