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Overview
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CK16 is a protein encoded by the KRT16 gene which is approximately 51, 2 kDa. CK16 is localised to the cytoskeleton and nucleus. It is involved in developmental biology, keratinization and cytoskeleton remodelling. It is an epidermis-specific type I keratin that functions as a regulator of innate immunity in response to skin barrier breach which is required for some inflammatory checkpoints for skin barrier maintenance. CK16 is expressed in the skin, liver and blood. Mutations in the KRT16 gene may result in pachyonychia congenital. STJ96958 was developed from clone 6F6 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CK16 proteins.
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