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Overview
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Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form.Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deminase (PAD)in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, isnot built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins areknown to contain citrulline. Proteins that normally contain citrulline residues include myelin basicprotein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin canget deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (atleast 80% of them) develop an immune response against proteins containing citrulline. Although theorigin of this immune response is not known, detection of antibodies reactive with citrullinecontainingproteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis.Immunogen: Deiminated murine fibrinogen peptide.
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