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Overview
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The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of C6 cells using CISH antibody (STJ116738) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of 293T cells, using CISH antibody (STJ116738) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 15s.
Anti-CISH antibody
Anti-CISH antibody
Catalog Number:
A001023592STJ
Mfr. No.:
STJ116738
Price:
$297
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