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Overview
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The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
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Overview
Western blot analysis of extracts of various cell lines, using CHRNG antibody (STJ110194) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10001 dilution.Lysates/proteins: 26ug per lane.Blocking buffer: 4% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 3s.
Anti-CHRNG antibody
Anti-CHRNG antibody
Catalog Number:
A001017044STJ
Mfr. No.:
STJ110194
Price:
$297
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