Name: Anti-CD59 antibody
Price: 297.00 USD

Overview
- This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of human CD59 (NP_001120695. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Cd59 Glycoprotein; 1f5 Antigen; 20 Kda Homologous Restriction Factor; Hrf-20; Hrf20; Mac-Inhibitory Protein; Mac-Ip; Mem43 Antigen; Membrane Attack Complex Inhibition Factor; Macif; Membrane Inhibitor Of Reactive Lysis; Mirl; Protectin; Cd Antigen Cd59 (Gene ID:966; UniProt:P13987)
  
  * For research use only