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Overview
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Recognizes a transmembrane glycoprotein of 140 and 180 kD which has been identified asNCAM (Neural Cell Adhesion Module). At the international Workshop on SCLC antibodies 123C3 hasbeen categorized as cluster 1 antibody. All cells in small cell carcinomas and carcinoids of the lung arestrongly positive for 123C3. A minority of cases of other major types of lung carcinoma are sometimespositive as well: however this positivity is generally weak and focal. Adenoid cystic carcinomas ofbronchial glands are strongly positive. Neuroblastoma's and Wilms tumors are usually also stainingstrongly positive. In non-small lung cell carcinomas, 123C3 staining has been associated with moreadvanced stage and a decreased survival after surgery. Furthermore, this antibody can be used tosupport diagnosis of lymphoma or to detect residual disease for cases of CD56 positive T/NK-celllymphoma in which the neoplastic lymphoid cells are small and show minimal atypia, especially in smallbiopsies.
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