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Overview
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CD45 is a protein encoded by the PTPRC gene which is approximately 147, 2 kDa. CD45 is localised to the cell membrane. It is involved in the activation of cAMP-dependent PKA, the innate immune system and dendritic cells developmental lineage pathway. It is a signalling molecule that regulates a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. It has been shown to be an essential regulator of T-and B-cell antigen receptor signalling. It functions through either interacting directly with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signalling. CD45 is expressed in the blood, liver, bone marrow, spleen and lymph node. Mutations in the PTPRC gene may result in plasmablastic lymphoma. STJ96948 was developed from clone 12A9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous CD45 proteins.
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