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Overview
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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Overview
Immunohistochemistry of paraffin-embedded mouse spleen using CD40 antibody (STJ11101171) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using CD40 antibody (STJ11101171) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat spleen using CD40 antibody (STJ11101171) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using CD40 Rabbit pAb (STJ11101171) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 5s.
Anti-CD40 antibody
Anti-CD40 antibody
Catalog Number:
A001018863STJ
Mfr. No.:
STJ11101171
Price:
$297
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