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Overview
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Recognizes a protein of 130‐140kDa, identified as CD22 (also known as BL‐CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B‐cell ontogeny, CD22 is first expressed in the cytoplasm of pro‐B and pre‐B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B‐cells, and while germinal center B‐cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid‐ bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B‐cell activation.
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